Rheumatoid arthritis (RA)

The BPRC has developed a range of models that allow examination of pathogenesis and treatment of rheumatoid arthritis.
The primary RA model, collagen-induced arthritis (CIA) in rhesus monkeys, has been well established and used for more than 20 years for preclinical validation of new treatments. To evaluate the chronic phase of RA, we have developed a CIA model in common marmosets. Of more recent date is the usage of the model for exploratory research into comorbidities of RA, including anemia and atherosclerosis.

Selected references

Modeling human arthritic diseases in nonhuman primates.
Vierboom MP, Jonker M, Bontrop RE, 't Hart B.
Arthritis Res Ther. 2005;7(4):145-54.

Preclinical models of arthritic disease in non-human primates.
Vierboom MP, Jonker M, Tak PP, 't Hart BA.
Drug Discov Today. 2007 Apr;12(7-8):327-35.

Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis.
Vierboom MP, Breedveld E, Kondova I, 't Hart BA.
Arthritis Res Ther. 2010;12(5):R200. doi: 10.1186/ar3172.

New drug discovery strategies for rheumatoid arthritis: a niche for nonhuman primate models to address systemic complications in inflammatory arthritis.
Vierboom M, Breedveld E, 't Hart BA.
Expert Opin Drug Discov. 2012 Apr;7(4):315-25. doi: 10.1517/17460441.2012.666523.

Safety, Biodistribution, and Efficacy of an AAV-5 Vector Encoding Human Interferon-Beta (ART-I02) Delivered via Intra-Articular Injection in Rhesus Monkeys with Collagen-Induced Arthritis.
Bevaart L, Aalbers CJ, Vierboom MP, Broekstra N, Kondova I, Breedveld E, Hauck B, Wright JF, Tak PP, Vervoordeldonk MJ.
Hum Gene Ther Clin Dev. 2015 Jun;26(2):103-12.

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