HIV

The BPRC has a long history in the preclinical research of new vaccine strategies for AIDS using SIV and SHIV models of the disease in rhesus monkeys. Anti-viral and gene therapy strategies to treat HIV infection have been explored in this model. Due to the effectiveness of HAART therapy HIV has become a chronic infectious disease raising new scientific questions on non-AIDS related morbidities in HIV patients. Our recently developed mild SIV infection model in rhesus monkeys provides a useful model for preclinical evaluation of anti-inflammatory drugs under condition of low levels of intermittently detectable virus replication.

Selected references

Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge.
Bogers WM, Davis D, Baak I, Kan E, Hofman S, Sun Y, Mortier D, Lian Y, Oostermeijer H, Fagrouch Z, Dubbes R, van der Maas M, Mooij P, Koopman G, Verschoor E, Langedijk JP, Zhao J, Brocca-Cofano E, Robert-Guroff M, Srivastava I, Barnett S, Heeney JL.
Virology. 2008 Dec 20;382(2):217-25. doi: 10.1016/j.virol.2008.09.016.

Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques.
Koopman G, Mortier D, Hofman S, Koutsoukos M, Bogers WM, Wahren B, Voss G, Heeney JL. J Gen Virol. 2009 Apr;90(Pt 4):915-26. doi: 10.1099/vir.2008.006148-0.

Protection in macaques immunized with HIV-1 candidate vaccines can be predicted using the kinetics of their neutralizing antibodies.
Davis D, Koornstra W, Mortier D, Fagrouch Z, Verschoor EJ, Heeney JL, Bogers WM.
PLoS One. 2011;6(12):e28974. doi: 10.1371/journal.pone.0028974. Epub 2011 Dec 28.

Immunization with apoptotic pseudovirus transduced cells induces both cellular and humoral responses: a proof of concept study in macaques.
Koopman G, Beenhakker N, Hofman S, Walther-Jallow L, Mäkitalo B, Mooij P, Anderson J, Verschoor E, Bogers WM, Heeney JL, Spetz AL.
Vaccine. 2012 Mar 28;30(15):2523-34. doi: 10.1016/j.vaccine.2012.01.082. Epub 2012 Feb 5.

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